A liposomal blend of folate, vitamin B6, vitamin B12, and trimethylglycine designed to support methylation and homocysteine balance with steady absorption.*
NuMedica Liposomal MethylSorb® is a combination formula designed to support methylation and homocysteine balance using a coordinated blend of folate, vitamin B6, vitamin B12, and trimethylglycine. These nutrients are delivered in a liposomal liquid format to support steady absorption and practical daily use.
This product is intended for adults who already understand methylation support and want a more comprehensive option that combines multiple methylation-related nutrients in a single formula.
Methylation depends on several nutrients working in coordination. Folate, vitamin B6, and vitamin B12 each play a role in how the body processes homocysteine, produces energy, and supports routine cellular maintenance.
Trimethylglycine (TMG) adds additional methyl group support, helping distribute the workload across multiple pathways rather than relying on a single nutrient.
Homocysteine is a normal byproduct of protein metabolism. Under typical conditions, it is continually processed with the help of folate, vitamin B12, vitamin B6, and related nutrients.
Supporting these nutrients together helps maintain steady metabolic function and supports cardiovascular and cellular balance as part of everyday physiology.
Liposomal delivery surrounds nutrients with phospholipids that resemble components of cell membranes. This structure supports absorption while allowing nutrients to enter circulation more gradually.
For individuals who have difficulty maintaining nutrient levels or who prefer liquid formats, liposomal delivery offers an alternative to capsules or tablets.
Liposomal MethylSorb® represents the most comprehensive option within this group of methylation-focused formulas. It combines multiple active B vitamins, TMG, and liposomal delivery rather than focusing on a single nutrient or pathway.
| Methyl-Plex B | Methyl Folate Optimizer | Liposomal MethylSorb | |
|---|---|---|---|
| Primary focus | System-level methylation support | Folate absorption and utilization | Comprehensive methylation and homocysteine support |
| Main nutrients | Active B vitamins + TMG | Folate with absorption cofactors | Folate, B6, B12, and TMG |
| Delivery format | Capsule | Capsule | Liposomal liquid |
| Complexity level | Moderate | Targeted | Most comprehensive |
| Best suited for | Coordinated B-vitamin support | Folate-focused refinement | Advanced methylation support in one formula |
NuMedica Liposomal MethylSorb® is intended for adults who want comprehensive methylation support without managing multiple individual supplements. It is most appropriate for those who already understand their nutrient needs and prefer a structured, all-in-one approach.
This product reflects a steady, system-oriented strategy rather than short-term intervention, fitting best within a long-term wellness routine supported by balanced nutrition, regular movement, and manageable stress.
Size: 60 Servings
Serving Size: 3 Pumps (0.5 mL)
Servings Per Container: 60
Directions: Take 3 pumps (0.5 mL) once per day or as directed by your healthcare practitioner. Shake well before use.
| Nutrient/Ingredient | Amount | % Daily ValueDV 1 |
|---|---|---|
|
Vitamin D3 (as cholecalciferol) (1,000 IU)
Vitamin D3
Vitamin D3 is the bioactive form of vitamin D that enhances calcium absorption and bone health. |
25 mcg | |
|
Vitamin B6 (as pyridoxal-5'-phosphate)
Vitamin B6
Vitamin B6 supports amino acid metabolism, cognitive development, and immune function. |
2.5 mg | |
|
Folate (as 750 mcg (6S)-5-methyltetrahydrofolic acid, glucosamine salt†, and 500 mcg calcium folinate)
Folate
Folate is a B vitamin important for DNA synthesis, cell division, and prenatal development. It supports cardiovascular and neurological health. |
2,125 mcg DFE | |
|
Vitamin B12 (625 mcg as methylcobalamin, 250 mcg hydroxycobalamin)
Vitamin B12
Vitamin B12 is essential for red blood cell formation, neurological function, and DNA synthesis. |
875 mcg | |
|
Trimethylglycine
Trimethylglycine
Trimethylglycine supports liver function, methylation, and homocysteine metabolism. |
60 mg | |
| Proprietary Blend |
50 mg | |
|
Lecithin (from sunflower) (non-GMO)
Lecithin
Lecithin is a source of phospholipids that support brain function, liver health, and fat metabolism. |
||
|
Glycerin (from sustainable palm) (kernel)
Glycerin
Glycerin is a sugar alcohol used to maintain moisture in products. It supports hydration and may soothe mucous membranes. |
||
| 1 The % Daily Value tells you how much a nutrient in a serving of food contributes to a daily diet. 2,000 calories a day is used for general nutrition advise. | ||
If you have a question not answered on this page, please consider submitting it in the Product Questions or Feedback section in the Discussion Forum below.
Liposomal MethylSorb is a combination formula that provides folate, vitamin B6, vitamin B12, and trimethylglycine in a liposomal liquid format. It is designed to support methylation and homocysteine balance using coordinated nutrients rather than a single vitamin.
Single-nutrient products focus on adjusting one nutrient at a time. Liposomal MethylSorb combines several nutrients that work together in methylation-related processes, offering a more comprehensive approach in one formula.
Liposomal delivery surrounds nutrients with phospholipids similar to cell membranes. This structure can support absorption and allows nutrients to enter circulation more gradually compared to standard capsules or tablets.
These B vitamins participate in related metabolic pathways, including the processing of homocysteine and routine cellular maintenance. Using them together helps support coordinated function rather than emphasizing a single pathway.
Trimethylglycine, also known as betaine, provides additional methyl group support. It helps distribute methylation demands across multiple pathways alongside folate and vitamin B12.
Liposomal MethylSorb focuses specifically on methylation-related nutrients. Some people use it instead of a broader B-complex, while others continue to use additional B vitamins depending on individual needs.
This product is often chosen by adults who already understand methylation support and want a single formula that combines key nutrients with an emphasis on absorption and consistency.
Liposomal MethylSorb is designed for consistent, ongoing use as part of a long-term wellness routine. Individual nutrient needs vary and are best considered within the context of overall diet and lifestyle.
We encourage you to take advantage of these related Wellness Resources on our website.
Methylation is a word that appears often in discussions about genetics, B vitamins, and stress, yet it is rarely explained in everyday terms. Rather than being a single switch or isolated pathway, methylation refers to a set of ongoing processes that help the body regulate, communicate, and adapt. Understanding it does not require advanced science; it only requires a clear view of how coordination works within living systems.
Many people suffer from Neuro-Endocrine-Immune diseases and disorders. This is a very deep and very specific group of issues, and this article will only scratch the surface of what these products can do. I encourage you to dig deeper into product descriptions if something piques your interest.
The MTHFR gene often comes up in conversations about folate, methylation, and homocysteine. Some people carry variations in this gene that affect how efficiently their bodies process certain nutrients, particularly folate. Understanding what MTHFR does can help explain why some individuals respond differently to diet, supplements, and lifestyle changes.
Reviews are from verified customers who purchased the product on SupplementRelief.com. They are intended to describe the quality and usefulness of the specific product i.e. "how is the product working for you?". Any benefits or results expressed are based on individual experiences that are unique, cannot be guaranteed, and have not been evaluated by the FDA. Consult with your healthcare practitioner to determine if any supplement you are considering purchasing would be a good option for your specific needs.
I have been using this product for years, but it was no longer available from another vendor I was using. Just as good as the other and in stock!
This is the fastest absorbing and most powerful B complex I've taken. It changed my blood work results to significantly better in less than a year!
absorbing b- fits much better. feeling better.
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