NuMedica MitoSpark™ supports natural cellular energy, renewal, and healthy aging with botanicals and antioxidants that promote mitochondrial health, focus, and vitality.*
NuMedica MitoSpark™ is a next-generation mitochondrial formula that supports the body's natural ability to renew and maintain healthy energy systems. It combines targeted botanicals and antioxidant compounds that help remove damaged cellular material, protect existing mitochondria, and sustain long-term metabolic resilience. When energy is produced efficiently at the cellular level, focus, stamina, and vitality follow naturally.*
Every heartbeat, thought, and breath depends on the energy created inside your cells. Mitochondria-often called the cell's "power plants"-convert nutrients into adenosine triphosphate (ATP), the molecule that fuels all biological activity. Over time, stress, poor nutrition, exposure to toxins, and aging can reduce mitochondrial efficiency. As a result, energy levels, recovery, and cognitive performance may decline. Supporting the renewal and protection of these organelles helps maintain steady energy, clearer focus, and greater resilience. To understand more about this process, see how mitochondria influence your energy and health.
MitoSpark™ promotes two essential cellular renewal processes-autophagy and mitophagy. Autophagy acts as the body's cleanup system, recycling worn-out cellular components into new building blocks. Mitophagy targets and removes damaged mitochondria, allowing healthy mitochondria to thrive. These natural repair cycles are key to maintaining efficient energy production, defending against oxidative stress, and supporting healthy aging.*
The formula emphasizes plant-based compounds that enhance these pathways and provide complementary antioxidant support. Together, they reinforce mitochondrial turnover and protect against the cellular stressors that can impair metabolism over time.*
MitoSpark™ and Mitochondrial Recharge® are designed to work together to maintain mitochondrial integrity throughout the energy cycle. Mitochondrial Recharge® restores ATP production by supplying direct cofactors, such as carnitine, NAC, and CoQ10. MitoSpark™ builds on that foundation, focusing on the renewal and recycling of aging mitochondria. Together, they form a comprehensive approach to supporting energy metabolism and long-term vitality.*
| Feature | MitoSpark™ | Mitochondrial Recharge® |
|---|---|---|
| Primary Focus | Cellular renewal, autophagy, and mitochondrial turnover | ATP production and direct mitochondrial energy restoration |
| Key Mechanism | Promotes removal of damaged mitochondria for healthier energy balance | Supplies cofactors and antioxidants to fuel energy metabolism |
| Formula Base | Botanical extracts and longevity compounds | Amino acids, minerals, and mitochondrial nutrients |
| Ideal For | Healthy aging, metabolic balance, and long-term energy resilience | Fatigue, low energy, and recovery support |
| Complementary Use | Pairs well with Foundation Essentials for daily nutrition | Pairs well with MitoSpark™ for comprehensive mitochondrial care |
Cellular renewal is most effective when supported by consistent lifestyle habits that promote balance across all body systems. Eating real, nutrient-dense food fuels your cells with essential substrates. Regular movement enhances circulation and oxygen delivery. Breathing with intention helps calm the nervous system and reduce oxidative stress. Clear, steady thinking supports emotional balance and healthy decision-making. These principles-outlined in the Four Foundations of Wellness-provide the framework for maintaining energy and longevity. MitoSpark™ complements these fundamentals by supporting the body's natural processes of cellular repair and renewal.*
Size: 90 Vegetable Capsules
Serving Size: 3 Capsules
Servings Per Container: 30
Directions: Take three capsules once per day or as directed by your healthcare practitioner.
| Nutrient/Ingredient | Amount | % Daily ValueDV 1 |
|---|---|---|
|
Gynostemma (as Gynostemma pentaphyllum (leaf) extract†, Gynostemma pentaphyllum (leaf) extract)
Gynostemma
Gynostemma is an adaptogenic herb that supports immune function, energy levels, and healthy aging by promoting antioxidant activity. |
450 mg | |
|
Pomegranate Extract (Punica granatum) (hull) extract (40% ellagic acid)
Pomegranate Extract
Pomegranate Extract is rich in polyphenols that support heart health, antioxidant defense, and healthy aging. |
350 mg | |
| Gotu Kola (Centella asiatica) (leaf) | 250 mg | |
|
Grape Seed Extract (Vitis vinifera) (seed) extract (95% proanthocyanidins)
Grape Seed Extract
Grape Seed Extract is rich in proanthocyanidins, antioxidants that support cardiovascular health, circulation, and protection from oxidative stress. |
250 mg | |
| Urolithin A | 215 mg | |
|
Green Tea Extract (Camellia sinensis) (leaf) extract (50% polyphenols)
Green Tea Extract
Green Tea Extract is rich in catechins, antioxidants that support metabolism, cardiovascular health, and cellular protection. |
200 mg | |
|
Resveratrol (from Polygonum cuspidatum (root) extract)
Resveratrol
Resveratrol is a polyphenol that supports cardiovascular health, cellular longevity, and antioxidant defense. |
200 mg | |
|
Maritime Pine (Pinus pinaster) (bark) extract (95% proanthocyanidins)
Maritime Pine
Maritime Pine extract contains proanthocyanidins that support circulation, cognitive health, and antioxidant defense. |
100 mg | |
| Spermidine Trihydrochloride | 10 mg | |
| 1 The % Daily Value tells you how much a nutrient in a serving of food contributes to a daily diet. 2,000 calories a day is used for general nutrition advise. | ||
If you have a question not answered on this page, please consider submitting it in the Product Questions or Feedback section in the Discussion Forum below.
Yes. Many people use Mitochondrial Recharge® to restore foundational energy and then add MitoSpark™ for ongoing mitochondrial renewal and longevity support. The two formulas address different aspects of cellular energy and work well together as part of a comprehensive wellness plan.
MitoSpark is intended for consistent, long-term use as part of a wellness routine focused on energy, balance, and healthy aging. Its benefits build gradually as your cells renew and adapt to improved nutrition and lifestyle habits.
No. MitoSpark™ supports natural cellular energy production without caffeine or other stimulants. It promotes steady vitality through improved mitochondrial efficiency rather than quick energy spikes.
Adults interested in supporting longevity, energy balance, and metabolic health can benefit from MitoSpark. It's especially relevant for those looking to maintain vitality as they age or manage fatigue linked to lifestyle and stress factors.
Yes. MitoSpark is formulated to complement foundational nutrition such as NuMedica Foundation Essentials or daily multivitamin programs. As always, discuss new supplements with your healthcare practitioner if you have existing medical conditions or take prescription medications.
We encourage you to take advantage of these related Wellness Resources on our website.
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Metabolic health is the foundation of energy, resilience, and healthy aging. Modern habits around food, movement, stress, and mindset have shifted dramatically-often eroding this foundation over time. The good news? By understanding how lifestyle shapes your metabolism, you can restore balance and vitality at any age.
Having more energy is simple once you know the causes of low energy and some straightforward solutions to combat low energy levels. This article will explain what you should know about poor energy levels and how to naturally boost them to reach healthy new levels.
Oxidative stress is a natural process that occurs when there is an imbalance of free radicals to antioxidants in the body, which ultimately causes damage to its cells and tissues. Oxidative stress is a natural process in aging, though long-term oxidative stress leads to chronic disease.
Coenzyme Q10 (CoQ10) is a naturally occurring compound that plays a critical role in cellular energy production and antioxidant defense. Found in every cell of the body, particularly in energy-demanding organs such as the heart and liver, CoQ10 supports mitochondrial function and helps protect against oxidative stress. As we age or face increased metabolic demands, CoQ10 levels decline - making supplementation an effective way to support cardiovascular and overall health.*
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