NuMedica Methyl-Plex B - Coordinated Methylation Support Formula
Methyl-Plex B
60 Vegetable Capsules
by NuMedica
NuMedica Methyl-Plex B
Comprehensive Methylation Support*
A coordinated B-vitamin formula designed to support methylation processes as a system. Combines active B vitamins with trimethylglycine to support everyday metabolic balance.*
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Description*
NuMedica Methyl-Plex B™ is a coordinated B-vitamin formula designed to support methylation as a system rather than through a single nutrient. It combines active forms of key B vitamins with trimethylglycine (TMG) to support everyday metabolic balance and routine cellular function.
This type of formula is often considered by adults who want structured methylation support without managing individual B vitamins separately.
Who Methyl-Plex B Is Intended For
Methyl-Plex B is commonly used in situations such as:
- Wanting system-level methylation support rather than a single-nutrient focus
- Seeking a balanced B-vitamin formula with active forms
- Supporting everyday energy and metabolic steadiness
- Preferring a coordinated approach over frequent supplement adjustments
- Looking for methylation support without adrenal or stress-focused formulas
In these situations, a comprehensive methylation-oriented formula is often chosen to support multiple pathways working together.
What This Formula Is Not Meant to Replace
Methyl-Plex B is not intended to replace medical care, address diagnosed genetic conditions, or act as a substitute for balanced nutrition and lifestyle habits. It is also not designed to function as a general stress or adrenal support formula.
This product is best understood as a focused option for methylation support rather than a broad wellness or energy supplement.
Methylation as a Coordinated Process
Methylation is an ongoing process that depends on several nutrients working together. Vitamins B2, B6, folate, and B12 each contribute to the body's energy production, nervous system function, and routine cellular maintenance.
Because these roles are interconnected, supporting the full system often feels more practical than emphasizing one vitamin in isolation.
Why Active B Vitamins Are Used
The B vitamins in Methyl-Plex B are provided in active forms that the body can use without additional conversion steps. This approach supports predictable participation in everyday metabolic processes.
Active forms are commonly chosen when efficiency, tolerance, or age-related changes in nutrient handling are considerations.
The Role of Trimethylglycine (TMG)
Trimethylglycine, also known as betaine, supplies methyl groups that support methylation alongside folate and vitamin B12. It plays a complementary role rather than replacing B vitamins.
Including TMG helps distribute metabolic demand across multiple pathways, supporting steadier balance instead of relying on a single nutrient.
How Methyl-Plex B Compares to Related Options
The formulas below represent the most common comparison points within the methylation category.
Methylation Support Formula Comparison Methyl-Plex B Methyl Folate Optimizer B-Replete Form Multi-nutrient methylation formula Single-nutrient folate focus Broad B-complex Primary actives per serving Active B vitamins plus TMG High-potency folate Full B-vitamin spectrum Release style Standard oral capsules Standard oral capsules Standard oral capsules Adjustability System-level support Targeted refinement Daily baseline Taste / format Capsules Capsules Capsules Best for Coordinated methylation support Higher or focused folate needs Energy and general stress support When a Different Option May Make Sense
Some individuals prefer single-nutrient folate or B12 formulas when only one component needs attention. Others choose a general B-complex when methylation support is not the primary goal.
Methyl-Plex B is most often selected when coordinated methylation support feels appropriate without expanding into stress-focused or adrenal formulas.
A Structured Approach to Methylation Support
NuMedica Methyl-Plex B™ is designed to fit into a long-term routine built on consistency rather than frequent changes. It supports methylation as an ongoing process rather than a short-term intervention.
This formula reflects a system-oriented approach for individuals who want clarity and balance in their methylation support strategy.
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Features*
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Directions
Size: 60 Vegetable Capsules
Serving Size: 1 Capsule
Servings Per Container: 60
Directions: Take one capsule once per day with a meal or as directed by your healthcare practitioner.
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Ingredients
Nutrient/Ingredient Amount % Daily ValueDV 1 Riboflavin (Vitamin B-2) (as riboflavin-5'-phosphate) Riboflavin
Riboflavin (Vitamin B2) supports energy metabolism, red blood cell formation, and antioxidant protection.
25 mg Vitamin B6 (as pyridoxal-5'-phosphate) Vitamin B6
Vitamin B6 supports amino acid metabolism, cognitive development, and immune function.
25 mg One Capsule Contains:
Folate (as (6S)-5-methyltetrahydrofolic acid, glucosamine salt†; (6S)-5-methyltetrahydrofolic acid, calcium salt) Folate
Folate is a B vitamin important for DNA synthesis, cell division, and prenatal development. It supports cardiovascular and neurological health.
2,040 mcg DFE Vitamin B12 (as methylcobalamin) Vitamin B12
Vitamin B12 is essential for red blood cell formation, neurological function, and DNA synthesis.
1,000 mcg Trimethylglycine (as anhydrous betaine) Trimethylglycine
Trimethylglycine supports liver function, methylation, and homocysteine metabolism.
500 mg 1 The % Daily Value tells you how much a nutrient in a serving of food contributes to a daily diet. 2,000 calories a day is used for general nutrition advise. -
Questions*
Questions
If you have a question not answered on this page, please consider submitting it in the Product Questions or Feedback section in the Discussion Forum below.
What is Methyl-Plex B?
Methyl-Plex B is a combination formula that provides several B vitamins in their active forms along with trimethylglycine (TMG). It is designed to support methylation as a coordinated process rather than focusing on a single nutrient.
How is Methyl-Plex B different from a regular B-complex?
Many B-complex formulas provide standard vitamin forms intended for general energy or stress support. Methyl-Plex B uses active forms of key B vitamins and is structured specifically around methylation-related pathways.
Why are active B vitamins used?
Active B vitamins do not require additional conversion before use. This can be relevant when nutrient demand is higher or when efficiency of processing varies with age or individual differences.
What is TMG and why is it included?
TMG stands for trimethylglycine, also known as betaine. It supplies methyl groups used in methylation and supports normal homocysteine handling alongside folate and vitamin B12.
Who is Methyl-Plex B designed for?
Methyl-Plex B is intended for adults who want coordinated methylation support without managing multiple individual supplements. It suits those looking for a structured, system-level approach.
How does this product relate to homocysteine balance?
Homocysteine is a normal byproduct of protein metabolism. The body processes it using nutrients such as folate, vitamin B12, vitamin B6, and TMG. Methyl-Plex B provides these nutrients together to support routine conversion processes.
Is Methyl-Plex B meant for long-term use?
Methyl-Plex B is commonly used as part of a consistent, long-term wellness routine. It is often paired with balanced nutrition, regular movement, adequate rest, and realistic stress management.
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Related Content*
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We encourage you to take advantage of these related Wellness Resources on our website.
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Magnesium and Your Health: How Are They Connected?Have you been feeling nauseous and weak? You may have a magnesium deficiency. Also known as hypomagnesemia, magnesium deficiency affects over 2.5% to 12% of the general population.
Taking magnesium supplements can help with your symptoms and improve your quality of life.
Understanding MTHFR: Its Role, Implications, and the Role of SupplementsThe MTHFR gene often comes up in conversations about folate, methylation, and homocysteine. Some people carry variations in this gene that affect how efficiently their bodies process certain nutrients, particularly folate. Understanding what MTHFR does can help explain why some individuals respond differently to diet, supplements, and lifestyle changes.
Why Take a CoQ10 Supplement?Coenzyme Q10 (CoQ10) is a naturally occurring compound that plays a critical role in cellular energy production and antioxidant defense. Found in every cell of the body, particularly in energy-demanding organs such as the heart and liver, CoQ10 supports mitochondrial function and helps protect against oxidative stress. As we age or face increased metabolic demands, CoQ10 levels decline - making supplementation an effective way to support cardiovascular and overall health.*
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Product Reviews*:
24 Found
Product Reviews*
Reviews are from verified customers who purchased the product on SupplementRelief.com. They are intended to describe the quality and usefulness of the specific product i.e. "how is the product working for you?". Any benefits or results expressed are based on individual experiences that are unique, cannot be guaranteed, and have not been evaluated by the FDA. Consult with your healthcare practitioner to determine if any supplement you are considering purchasing would be a good option for your specific needs.
Always Great!
on April 7, 2025
- Verified PurchaseI have been taking Methyl-Plex B for many years under the direction of my physician. I have had labs at least once a year and my results are always spot on! Definitely recommend.
on March 7, 2025
- Verified PurchaseThis product has reduced and kept my homocysteine level at normal. Definitely works!!
Great!
on October 2, 2024
- Verified PurchaseProven by lab work to work!
Great supplement
on August 7, 2023
- Verified PurchaseI can't be without. Recommended by my physician and it has made such a difference in my health
I Finally Have Energy
on February 6, 2023
- Verified PurchaseThese vitamins are a life-saver. A naturopath recommended them to me, and I'm so grateful she did. I finally have energy to live life, the way I always saw others living. My cognition is improved, and I'm calm and not unduly anxious like I used to be. It's amazing how giving your body the nutrients it needs can improve health in multiple ways.
on September 20, 2022
- Verified PurchaseMy homocysteine level has dropped down to the middle of normal.
Med. Tech.(ASCP)
on January 26, 2022
- Verified PurchaseHas reduced homocysteine to a normal level, a must for anyone with MTHFR.
Great!
on November 1, 2021
- Verified PurchaseI taken these for 10 years under a physicians care and I have labs ran often which show that my NuMedica supplements are doing their job!
on September 27, 2021
- Verified PurchaseHelps with PSC, AS, And UC by providing easily absorbed b vitamins essential to calming inflammation
on June 10, 2021
- Verified PurchaseHelps with energy
Great
on May 11, 2021
- Verified PurchaseGood product
Great!
on April 6, 2021
- Verified PurchaseAccording to lab results and feeling better I will keep ordering!
on February 13, 2021
- Verified Purchasevery beneficial
Great!
on September 29, 2020
- Verified PurchaseLabs prove they work!
Methyl-Plex B
on September 28, 2020
- Verified PurchaseGreat product, helpful with issues I need it for. Great quality company as well.
on September 28, 2020
- Verified PurchaseExcellent product for your B vitamin needs
have used for years
on July 8, 2020
- Verified Purchasehave used under doctor's supervision due to a genetic problem that makes me unable to process b vitamins correctly
Ms
on June 1, 2020
- Verified Purchasebeen on this for 3 yrs blood test all great
Physician Prescribed
on April 7, 2020
- Verified PurchaseAfter being diagnosed with MTHFR Gene as well as being chronically ill my doc prescribed this supplement. I have been taking it since 2011 and labs confirm that it works great for me.
on March 22, 2020
- Verified PurchaseI have felt so much better since starting on this product approx 75 days ago...calmer, yet with more energy! Thank you!
on October 31, 2019
- Verified Purchasegreat product of superior grade!
Great Supplement
on September 4, 2019
- Verified PurchaseThis was prescribed by my physician since I am MTHFR. I've taken it for several years and it does the job.
Great
on April 30, 2019
- Verified PurchaseNever any problems with receiving my items, and product is always top quality
Methylation
on February 19, 2018
- Verified PurchaseGreat all purpose b vitamin combo .
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