NuMedica Methyl Folate - Active Folate Support for Methylation Needs
Methyl Folate
60/120 Vegetable Capsules
by NuMedica
NuMedica Methyl Folate
The Most Biologically Active Form of Folate (5-MTHF)*
A single-nutrient folate formula providing 5-MTHF in an active form. Used when targeted folate support is needed within methylation-related processes.*
Warning: Array to string conversion in /home/cdndelivery/public_html/php/show_project_brand_product.php on line 840
Array
-
Description*
NuMedica Methyl Folate™ provides folate in its active form, 5-MTHF, which the body can use directly. Folate plays a routine role in methylation processes and normal homocysteine metabolism, supporting everyday cellular and cardiovascular function.
This product is typically chosen by adults who want straightforward folate support without additional cofactors, delivery enhancements, or multi-nutrient formulas.
Who Methyl Folate Is Intended For
Methyl Folate is often used in situations such as:
- Wanting single-nutrient folate support rather than a full B-complex
- Preferring active folate without additional methylation cofactors
- Supporting routine methylation needs with a simple formula
- Looking for a foundational option that can be adjusted later if needed
- Already using other B vitamins separately
In these situations, a standalone folate formula is often selected to keep supplementation focused and uncomplicated.
What This Formula Is Not Meant to Replace
Methyl Folate is not intended to replace medical care, address diagnosed genetic conditions, or function as a comprehensive methylation or stress-support formula. It is also not designed to provide the broader nutrient coverage found in multi-B or adrenal-focused products.
This product serves a specific role within methylation support rather than acting as a complete system-level solution.
Why Active Folate Is Used
Folate participates in ongoing metabolic processes related to methylation, cell maintenance, and homocysteine handling. In its active form, 5-MTHF is already prepared for use and does not require additional conversion steps.
These processes occur within broader methylation pathways that influence how the body manages routine cellular repair and metabolic balance.
Folate, Homocysteine, and Everyday Metabolism
Homocysteine is a normal byproduct of protein metabolism. Under typical conditions, it is continually processed with the help of folate, vitamin B12, vitamin B6, and related nutrients.
Providing folate in its active form supports this normal handling as part of everyday metabolic activity.
How Methyl Folate Compares to Related Options
The formulas below represent the most common comparison points for individuals considering targeted folate support.
Folate and Methylation Support Options Methyl Folate Methyl Folate HP Methyl Folate Optimizer Methyl-Plex B Form Single-nutrient folate Single-nutrient folate Folate with cofactors Multi-nutrient B formula Primary active per serving 5-MTHF 5-MTHF (higher potency) 5-MTHF plus supporting nutrients Active B vitamins plus trimethylglycine Release style Standard oral capsule Standard oral capsule Standard oral capsule Standard oral capsule Adjustability Foundational folate support Increased folate support Absorption-focused refinement System-level methylation support Taste / format Capsule Capsule Capsule Capsule Best for Simple, targeted folate use Higher folate demand Folate support with absorption considerations Coordinated methylation support When a Different Option May Make Sense
Some individuals prefer broader methylation formulas when multiple nutrients need attention at once. Others choose higher-potency or absorption-focused folate options as needs change.
Methyl Folate is most often selected when simplicity and flexibility are priorities.
A Focused Approach to Folate Support
NuMedica Methyl Folate™ is designed to fit into a long-term wellness routine built around consistency rather than complexity. It provides a clear, targeted option for supporting folate needs as part of everyday metabolic balance.
This formula reflects a restrained approach for individuals who want precise nutrient support without unnecessary additions.
-
Features*
-
Directions
Product ServingSize NumberServings Directions Methyl Folate 5-MTHF - 60 Capsules 1 Capsule 60 Take one capsule daily or as directed by your healthcare practitioner. Methyl Folate 5-MTHF - 120 Capsules 1 Capsule 120 Take one capsule daily or as directed by your healthcare practitioner. -
Ingredients
Nutrient/Ingredient Amount % Daily ValueDV 1 Folate (as (6S)-5-methyltetrahydrofolic acid, glucosamine salt)† Folate
Folate is a B vitamin important for DNA synthesis, cell division, and prenatal development. It supports cardiovascular and neurological health.
1,360 mcg DFE One Capsule Contains:
1 The % Daily Value tells you how much a nutrient in a serving of food contributes to a daily diet. 2,000 calories a day is used for general nutrition advise. -
Questions*
Questions
If you have a question not answered on this page, please consider submitting it in the Product Questions or Feedback section in the Discussion Forum below.
What is Methyl Folate?
Methyl Folate provides folate in its active form, 5-MTHF, which the body can use directly. Folate supports routine methylation processes and normal homocysteine metabolism as part of everyday cellular function.
How is Methyl Folate different from a regular folic acid supplement?
Regular folic acid must be converted by the body before it can be used. Methyl Folate supplies folate in an already active form, avoiding the need for that conversion step.
How is Methyl Folate different from Methyl-Plex B?
Methyl Folate provides single-nutrient folate support. Methyl-Plex B combines folate with other active B vitamins and trimethylglycine to support methylation as a coordinated system. The choice depends on whether support is needed for folate alone or for multiple related nutrients.
What is the difference between Methyl Folate and Methyl Folate HP?
Both products provide folate in the form of 5-MTHF. Methyl Folate HP delivers a higher amount per serving, which is sometimes chosen when folate needs are greater or more focused.
Does Methyl Folate affect homocysteine levels?
Homocysteine is a normal byproduct of protein metabolism. Folate plays a role in how the body processes homocysteine alongside nutrients such as vitamin B12 and vitamin B6. Methyl Folate supports this routine metabolic process.
Is Methyl Folate meant for long-term use?
Methyl Folate is commonly used as part of a consistent, long-term wellness routine. Some people adjust their approach over time depending on overall nutrient needs and dietary intake.
Who might consider a different option instead?
Individuals seeking broader methylation support may prefer a multi-nutrient formula. Those looking for higher-potency or absorption-focused folate support may consider other folate-specific options. Methyl Folate fits best when simplicity and targeted support are priorities.
-
Related Content*
Additional Resources
We encourage you to take advantage of these related Wellness Resources on our website.
Functional Medicine - A Systems-Based, Root-Cause Approach to Long-Term WellnessFunctional medicine examines how the body's systems interact and looks for underlying drivers of imbalance rather than treating symptoms in isolation. It emphasizes prevention, personalization, and practical daily habits that strengthen long-term health and resilience.
Methylation Explained Without the Biochemistry DegreeMethylation is a word that appears often in discussions about genetics, B vitamins, and stress, yet it is rarely explained in everyday terms. Rather than being a single switch or isolated pathway, methylation refers to a set of ongoing processes that help the body regulate, communicate, and adapt. Understanding it does not require advanced science; it only requires a clear view of how coordination works within living systems.
Supplements for Fatigue, Brain Fog, Memory, Sleep, ADHD & Behavioral Issues?Many people suffer from Neuro-Endocrine-Immune diseases and disorders. This is a very deep and very specific group of issues, and this article will only scratch the surface of what these products can do. I encourage you to dig deeper into product descriptions if something piques your interest.
Understanding Estrogen: Why It's Important for Both Men and WomenEstrogen is an important hormone that plays a vital role in the development and functioning of the reproductive system in both men and women. Understanding estrogen and its importance for overall health is essential for everyone.
Understanding MTHFR: Its Role, Implications, and the Role of SupplementsThe MTHFR gene often comes up in conversations about folate, methylation, and homocysteine. Some people carry variations in this gene that affect how efficiently their bodies process certain nutrients, particularly folate. Understanding what MTHFR does can help explain why some individuals respond differently to diet, supplements, and lifestyle changes.
Understanding Testosterone and Natural Ways to Boost ItFeeling unusually tired, losing muscle mass, or experiencing mood drops? These might be signs of low testosterone, a vital hormone for men's health. Understanding testosterone is key to maintaining vitality and well-being. In this post, we explore what testosterone is, how it changes over time, how to recognize issues, and natural ways to boost your levels. Dive in to discover how you can naturally enhance your health and energy.
Whole Foods Plant-Based (WFPB) DietHow many times have you jumped on-board the diet train with high hopes of weight loss and improved health, only to discover limited food choices, difficulty staying on-track, and few measurable health benefits? Diet fads come and go, but one - the whole foods, plant-based diet (WFPB)- isn't a fad.
-
Product Reviews*:
10 Found
Product Reviews*
Reviews are from verified customers who purchased the product on SupplementRelief.com. They are intended to describe the quality and usefulness of the specific product i.e. "how is the product working for you?". Any benefits or results expressed are based on individual experiences that are unique, cannot be guaranteed, and have not been evaluated by the FDA. Consult with your healthcare practitioner to determine if any supplement you are considering purchasing would be a good option for your specific needs.
Nu Medca Methyl Folate
on January 23, 2025
- Verified PurchaseBecause I don't methylate well, I was prescribed this supplement by my health care practitioner. I find it very helpful. I use several other Nu Medica products and find them to be excellent products.
Surprising Bonus Effect
on December 11, 2024
- Verified PurchaseI got this stuff to try it for one problem, then was shocked when it help paxil lift my depression more and give me a more consistent level than with just the paxil ! So I Will be a happy continuous user !
Love it!
on January 18, 2023
- Verified PurchaseI have MTHFR & this product helps!
on August 3, 2021
- Verified Purchaseenjoy the product and like that it is vegetable capsule.
on July 16, 2021
- Verified PurchaseGreat product
on April 21, 2021
- Verified Purchasegreat
on August 8, 2020
- Verified PurchaseGreat
Wonderful product
on December 30, 2019
- Verified PurchaseWonderful product
Great products and great service
on September 6, 2018
- Verified PurchaseNuMedica products were recommended by our Homeopathic Doctor, also an MD. We have appreciated how well our bodies have responded over the past few years. Being in our 70's and still hiking and working and not getting sick is very important to us. We are also very happy with the supplier, Supplement Relief. Their turnaround time of delivery is excellent and their pricing is very fair.
NiMedica supplement
on December 17, 2017
- Verified PurchaseI was able to find the supplement easily and received it quickly.
Related Products: 8 Found
These products are similiar to, or are often purchased in conjunction with the product featured on this page.NuMedica
B-RepleteAdrenal, Neurological & Stress Response Support*
90/180 Vegetable CapsulesComprehensive activated B-complex designed to support daily energy, stress resilience, and nervous system balance for adults under ongoing physical or mental demand.*Activated B Vitamins Gluten Free Quatrefolic Vegetable Capsule VegetarianSKU: NM150, NM236 - UPC: 812527011502
Adrenal, Neurological & Stress Response Support*Comprehensive activated B-complex designed to support daily energy, stress resilience, and nervous system balance for adults under ongoing physical or mental demand.*
NuMedica
Corti-B PlexAdrenal Hormone Production Formula with Bioflavonoids*
120 Vegetable CapsulesA targeted B-vitamin formula used when stress feels physically draining. Emphasizes nutrients commonly associated with adrenal hormone production rather than broad daily B-complex support.*Activated B Vitamins Gluten Free Quatrefolic Vegetable Capsule Vegetarian PopularSKU: NM81 - UPC: 812527010819
Adrenal Hormone Production Formula with Bioflavonoids*A targeted B-vitamin formula used when stress feels physically draining. Emphasizes nutrients commonly associated with adrenal hormone production rather than broad daily B-complex support.*
NuMedica
Liposomal Hydroxy B12Slow-Release, Long-Acting Form of Vitamin B12*
60 ServingsA liposomal vitamin B12 formula providing hydroxocobalamin for slower, steadier availability. Used when gentler, sustained B12 delivery is preferred over fast-acting formats.*Gluten Free VegetarianSKU: NM544 - UPC: 812527015449
Slow-Release, Long-Acting Form of Vitamin B12*A liposomal vitamin B12 formula providing hydroxocobalamin for slower, steadier availability. Used when gentler, sustained B12 delivery is preferred over fast-acting formats.*
NuMedica
Liposomal MethylSorbPowerful Blend of Folate, B6 and B12*
60 ServingsA liposomal blend of folate, vitamin B6, vitamin B12, and trimethylglycine designed to support methylation and homocysteine balance with steady absorption.*Activated B Vitamins Gluten Free Quatrefolic VegetarianSKU: NM122 - UPC: 812527015159
Powerful Blend of Folate, B6 and B12*A liposomal blend of folate, vitamin B6, vitamin B12, and trimethylglycine designed to support methylation and homocysteine balance with steady absorption.*
NuMedica
Methyl B-12 HPSupports Healthy Homocysteine Levels*
60 LozengesA high-potency vitamin B12 formula providing methylcobalamin in a lozenge format. Used when targeted, active B12 support is preferred without additional methylation nutrients.*Gluten Free Vegetarian PopularSKU: NM129 - UPC: 812527011298
Supports Healthy Homocysteine Levels*A high-potency vitamin B12 formula providing methylcobalamin in a lozenge format. Used when targeted, active B12 support is preferred without additional methylation nutrients.*
NuMedica
Methyl Folate HPHigh-Potency, Biologically-Active Folate with 5,200 mcg per Capsule *
60 Vegetable CapsulesA high-potency folate formula providing 5-MTHF in an active form. Used when increased folate intake is needed without additional B vitamins or absorption enhancers.*Gluten Free Quatrefolic Vegetable Capsule VegetarianSKU: NM967 - UPC: 812527010109
High-Potency, Biologically-Active Folate with 5,200 mcg per Capsule *A high-potency folate formula providing 5-MTHF in an active form. Used when increased folate intake is needed without additional B vitamins or absorption enhancers.*
NuMedica
Methyl Folate OptimizerAdvanced Methylation Support*
60 Vegetable CapsulesA refined folate formula designed to support absorption and utilization rather than dose alone. Combines active folate with complementary nutrients to support methylation-related processes.*Activated B Vitamins Gluten Free Quatrefolic Vegetable Capsule VegetarianSKU: NM305 - UPC: 812527010116
Advanced Methylation Support*A refined folate formula designed to support absorption and utilization rather than dose alone. Combines active folate with complementary nutrients to support methylation-related processes.*
NuMedica
Methyl-Plex BComprehensive Methylation Support*
60 Vegetable CapsulesA coordinated B-vitamin formula designed to support methylation processes as a system. Combines active B vitamins with trimethylglycine to support everyday metabolic balance.*Activated B Vitamins Gluten Free Quatrefolic Vegetable Capsule VegetarianSKU: NM76 - UPC: 812527010765
Comprehensive Methylation Support*A coordinated B-vitamin formula designed to support methylation processes as a system. Combines active B vitamins with trimethylglycine to support everyday metabolic balance.*
Since 2010 SupplementRelief.com has provided professional-grade supplements supported by practical wellness content focussed on healthy living, risk reduction, and chronic disease elimination.
SupplementRelief.com promotes a lifestyle of Well-Being with emphasis on whole-foods nutrition, reasonable exercise, stress management, proper sleep, and the use of targeted, high-quality supplements to augment what is missing in our diet. We encourage others to live better through making small, gradual, healthy changes to lifestyle behaviors.
Jay is an original founder of SupplementRelief.com and has provided customer service, managed and operated the business ever since.
We welcome your 
call at (888) 424-0032 or 
email anytime. We can't always respond immediately but we will at our earliest opportunity. We are even known to respond after hours and on weekends! Learn more about us.
-
Discussion Forum
Questions or Feedback?Ask questions. Share your thoughts. Note that we cannot answer questions relating to specific medical conditions - please refer those to your qualified healthcare provider.
Post a new Comment or Reply to an existing one. Help for using the Discussion Forum.
Discussion Forum Help
Comments are displayed in order of the last one posted so the most recent one is at the top and the oldest one at the bottom.
Replies within a Comment are displayed in reverse order with the oldest one at the top and the most recent one at the bottom.
Each post identifies
who made the post and the 
date and time the post was made.Mouse over the icons for tooltips that explain what they mean.
If you see this icon you can attach an Audio file to your post.
If you see this icon you can attach a Document file to your post.
If you see this icon you can attach an Image file to your post.
If you see this icon you can attach a Video file to your post.
You will see the
Ban icon (Report Post as SPAM) immediately following the Timestamp of the post. Click this icon if you feel strongly that the content posted is not appropriate and should be reviewed by the Forum Moderator. You will be provided with a confirmation dialog to be sure you wish to submit this post for review. If submitted, the Forum Moderator will be notified to review the post and will determine what type of action to take.Click
in the upper right corner of this Help modal or anywhere on the web page outside of the modal to exit Help.
Session Expired from Inactivity
Do you want to?
9618 Jefferson Highway, Suite D-191
Baton Rouge LA 70809-9636
(888) 424-0032 |
support@supplementrelief.com
* Disclaimer: This page is available exclusively for SupplementRelief.com clients. None of the information on this website is intended to replace your relationship with your healthcare provider(s). Nothing should be considered medical advice. The information, knowledge, and experience shared on this website are the opinions of SupplementRelief.com. This site and its content are intended to enhance your knowledge base as YOU MAKE YOUR OWN HEALTHCARE DECISIONS in partnership with your qualified health professional.
* These statements have not been evaluated by the Food and Drug Administration. These products and services are not intended to diagnose, treat, cure, or prevent disease.
* There is NO GUARANTEE OF SPECIFIC RESULTS for the products or services offered, and the RESULTS CAN VARY for each individual. Any results claimed by our customers are based on individual experiences that are unique and cannot be guaranteed.
FirstFitness Nutrition and NuMedica may be promoted and sold on the internet ONLY by Authorized Resellers who have been approved by and have registered their website domain with these companies. They strictly prohibit, and actively monitor, the UNAUTHORIZED SALE or RESALE of their products in ALL online public shopping portals including Amazon, eBay, and others and into other countries. All products purchased in SupplementRelief.com are for PERSONAL USE ONLY and CANNOT BE RESOLD to others. Please report violations of Reseller Policy directly to FirstFitness Nutrition at 800.621.4348 and to NuMedica at 800.869.8100.
The content and photographs on this website are copyrighted or Licensed Material and may not be downloaded for other than personal use. Republication, retransmission, reproduction, or any other use of the content or photographs is prohibited. ©2010-2024 SupplementRelief.com.
Are you sure you want to remove this item?